Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0699
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0699
Status: annotated
Amino acids: 314
Structure source: AlphaFold

GO

GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.882

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
1	20	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
1	21	SignalP_EUK	SignalP-noTM	SignalP-noTM
157	260	SUPERFAMILY	SSF54534	FKBP-like
139	270	Pfam	PF13145	PPIC-type PPIASE domain
139	270	InterPro	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type
1	36	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
5	311	PANTHER	PTHR47245	PEPTIDYLPROLYL ISOMERASE
1	18	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
195	216	ProSitePatterns	PS01096	PpiC-type peptidyl-prolyl cis-trans isomerase signature.
195	216	InterPro	IPR023058	Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
19	36	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
37	314	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7	18	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
158	257	ProSiteProfiles	PS50198	PpiC-type peptidyl-prolyl cis-trans isomerase family profile.
158	257	InterPro	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type
152	283	Gene3D	G3DSA:3.10.50.40	-
152	283	InterPro	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0699	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
7				0.882
3				0.783
4				0.254

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
2NV	6VJ6	Q81CB1	279.4 Da LogP 0.44 TPSA 72.2	✓ Ro5	✓ Clean	`CCOCCOCCOCCOCCOC[C@@H](C)N`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC5859031	0.550	294.4 Da LogP 1.13 TPSA 55.4	✓ Ro5	✓ Clean	`CCOCCOCCOCCOCCOCCOCC`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA0699