Protein profile

PA0703

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA0703 Structure source: AlphaFold UniProt Q9I5M3

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Amino acids 438

Annotations 5

Features 55

PDB binders 0

Druggability 0.81

Overview

Basic information about this protein and its source genome.

Accession: PA0703
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0703
Status: annotated
Amino acids: 438
Structure source: AlphaFold

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.81

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015293 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

55 records

Show feature table

Start	End	DB	Term	Name
136	155	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
273	295	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
369	393	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
112	116	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	19	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
394	398	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17	237	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
17	237	InterPro	IPR036259	MFS transporter superfamily
307	325	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
16	425	SUPERFAMILY	SSF103473	MFS general substrate transporter
16	425	InterPro	IPR036259	MFS transporter superfamily
327	331	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
241	258	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
79	89	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20	43	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
335	357	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
44	54	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
212	239	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
57	79	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
117	135	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
305	326	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
190	211	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
55	78	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
18	427	ProSiteProfiles	PS50850	Major facilitator superfamily (MFS) profile.
18	427	InterPro	IPR020846	Major facilitator superfamily domain
402	419	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
20	42	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
370	392	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
332	357	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
238	425	Gene3D	G3DSA:1.20.1250.20	MFS general substrate transporter like domains
238	425	InterPro	IPR036259	MFS transporter superfamily
420	438	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
399	419	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
259	269	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
160	182	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
192	214	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	429	PANTHER	PTHR43528	ALPHA-KETOGLUTARATE PERMEASE
179	189	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
358	368	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
294	304	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
90	111	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
92	111	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
227	422	Pfam	PF00083	Sugar (and other) transporter
227	422	InterPro	IPR005828	Major facilitator, sugar transporter-like
20	216	Pfam	PF00083	Sugar (and other) transporter
20	216	InterPro	IPR005828	Major facilitator, sugar transporter-like
240	258	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
78	94	ProSitePatterns	PS00216	Sugar transport proteins signature 1.
78	94	InterPro	IPR005829	Sugar transporter, conserved site
126	148	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
128	153	ProSitePatterns	PS00217	Sugar transport proteins signature 2.
128	153	InterPro	IPR005829	Sugar transporter, conserved site
270	293	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
156	178	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	229	FunFam	G3DSA:1.20.1250.20:FF:000001	Dicarboxylate MFS transporter

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0703	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.81
16				0.45