Protein profile

PA0704

amidase

Genome: NC_002516.2

Gene: PA0704 Structure source: AlphaFold UniProt Q9I5M2
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Amino acids 464
Annotations 1
Features 8
PDB binders 4
Druggability 0.565

Overview

Basic information about this protein and its source genome.

Accession
PA0704
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0704
Status
annotated
Amino acids
464
Structure source
AlphaFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
40.152
Human E-value
1.86e-12
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.565
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTALHDLPGTRLLALFARRELSPGEYYEHLLAHIQRWEPHLNALYRFDPQRVREQAAAATERWRKGQPKGPLDGLPVTIKELIATAGEPIPLGSAATALQPAPCDAPPAARLREAGAIVLAKTTVPDFGMLSSGLSSFHGVTRNPWNLANNTGGSSSGAAAAATAGYGPLHLGTDIGGSVRLPAGWCGLVGFKPSLGRIPIDPYYTGRCAGPMTRCMDDCLLLMRYLAQPDARDATSLPPEVLDWSAEPLSVRGLRVGLQLDPGCGLQPDAEIRAAIEAAARLFEEHGAQLRIVEPLMDRSLLDGLNDFWRARLWSELLLLDETRRARVLPYVHAWAEGGARVSGVDAVRGFNQTFEMRRRAARLFGEIDLLLTPTNQVEAFPADWASPLNDPQRPFEHIVFTVPWNMGEQPALSINCGFTAAGMPIGLQLVAPRFADTWLLRIGKTYEGWRGPIHGWPRPPAD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
2 455 Gene3D G3DSA:3.90.1300.10 Amidase signature (AS) domain
2 455 InterPro IPR036928 Amidase signature (AS) superfamily
2 451 SUPERFAMILY SSF75304 Amidase signature (AS) enzymes
2 451 InterPro IPR036928 Amidase signature (AS) superfamily
11 449 PANTHER PTHR11895 TRANSAMIDASE
11 449 InterPro IPR000120 Amidase
28 442 Pfam PF01425 Amidase
28 442 InterPro IPR023631 Amidase signature domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0704
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.565

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ACA
3A2Q
P13398 131.2 Da LogP 0.59 TPSA 63.3 ✓ Ro5 ✓ Clean C(CCC(=O)O)CCN
CXS
4YJI
C3UWD1 221.3 Da LogP 1.19 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCCS(=O)(=O)O
GJY
6DII
Q7XJJ7 344.5 Da LogP 7.38 TPSA 26.3 1 viol. ✓ Clean CC/C=C\C/C=C\C/C=C\CCCCCCCC[P@](=O)(OC)F
TYL
4YJI
C3UWD1 151.2 Da LogP 1.35 TPSA 49.3 ✓ Ro5 ✓ Clean CC(=O)Nc1ccc(cc1)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.