Protein profile

PA0707

transcriptional regulator ToxR

Genome: NC_002516.2

Gene: regA toxR PA0707 Structure source: AlphaFold UniProt P09852

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Amino acids 259

Annotations 2

Features 6

PDB binders 0

Druggability 0.857

Overview

Basic information about this protein and its source genome.

Accession: PA0707
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: regA toxR PA0707
Status: annotated
Amino acids: 259
Structure source: AlphaFold

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.857

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
18	255	Gene3D	G3DSA:3.20.20.450	EAL domain
18	255	InterPro	IPR035919	EAL domain superfamily
21	252	SUPERFAMILY	SSF141868	EAL domain-like
21	252	InterPro	IPR035919	EAL domain superfamily
22	248	Pfam	PF00563	EAL domain
22	248	InterPro	IPR001633	EAL domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0707	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.857
8				0.374
3				0.293