Protein profile

PA0710

lactoylglutathione lyase

Genome: NC_002516.2

Gene: gloA2 PA0710 Structure source: Experimental + AlphaFold UniProt Q9I5L8
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Amino acids 131
Annotations 4
Features 12
PDB binders 17
Druggability 0.77

Overview

Basic information about this protein and its source genome.

Accession
PA0710
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
gloA2 PA0710
Status
annotated
Amino acids
131
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004462 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872 Binding to a metal ion. GO:0019243 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.899
Human E-value
5.7e-23
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.77
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004462 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
  • GO:0046872 Binding to a metal ion.
  • GO:0019243 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 126 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
2 126 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain
2 129 PANTHER PTHR46036 LACTOYLGLUTATHIONE LYASE
3 127 NCBIfam TIGR00068 lactoylglutathione lyase
3 127 InterPro IPR004361 Glyoxalase I
1 131 Gene3D G3DSA:3.10.180.10 -
1 131 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
2 123 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
2 123 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
1 127 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1 127 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
3 124 CDD cd16358 GlxI_Ni

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4MTS
X-ray 1.80 Å A,B
100.0% 1-131
PDBe RCSB PDBj File
Viewing
PDB 4MTR
X-ray 1.83 Å A,B
100.0% 1-131
PDBe RCSB PDBj File
Loaded
PDB 4MTQ
X-ray 2.17 Å A,B
100.0% 1-131
PDBe RCSB PDBj File
Loaded
PDB 4MTT
X-ray 2.17 Å A,B
100.0% 1-131
PDBe RCSB PDBj File
Loaded
AlphaFold PA0710
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.77

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.52 0.022
2 1.01 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

127 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
SIN
4MTQ 2.17 Å Open crystal
118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O
TAM
4MTT 2.17 Å Open crystal
163.2 Da LogP -1.17 TPSA 86.7 ✓ Ro5 ✓ Clean C(CO)C(CCO)(CCO)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.