Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0715
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0715
Status: annotated
Amino acids: 318
Structure source: AlphaFold

EC

2.7.7.49

GO

GO:0046872 Binding to a metal ion. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0003964 Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism. GO:0006278 A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.577

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

2.7.7.49

Gene Ontology (GO)

5

GO:0046872 Binding to a metal ion.
GO:0003723 Binding to an RNA molecule or a portion thereof.
GO:0003964 Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
GO:0051607 Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
GO:0006278 A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
1	235	ProSiteProfiles	PS50878	Reverse transcriptase (RT) catalytic domain profile.
1	235	InterPro	IPR000477	Reverse transcriptase domain
57	237	PANTHER	PTHR34047	NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED
40	255	CDD	cd03487	RT_Bac_retron_II
40	255	InterPro	IPR000123	RNA-directed DNA polymerase (reverse transcriptase), msDNA
175	186	PRINTS	PR00866	RNA-dependent DNA-polymerase (msDNA) signature
175	186	InterPro	IPR000123	RNA-directed DNA polymerase (reverse transcriptase), msDNA
89	107	PRINTS	PR00866	RNA-dependent DNA-polymerase (msDNA) signature
89	107	InterPro	IPR000123	RNA-directed DNA polymerase (reverse transcriptase), msDNA
142	155	PRINTS	PR00866	RNA-dependent DNA-polymerase (msDNA) signature
142	155	InterPro	IPR000123	RNA-directed DNA polymerase (reverse transcriptase), msDNA
40	235	Pfam	PF00078	Reverse transcriptase (RNA-dependent DNA polymerase)
40	235	InterPro	IPR000477	Reverse transcriptase domain
39	260	SUPERFAMILY	SSF56672	DNA/RNA polymerases
39	260	InterPro	IPR043502	DNA/RNA polymerase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0715	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.577
5				0.253
7				0.218

PA0715