Protein profile

PA0716

hypothetical protein

Genome: NC_002516.2

Gene: PA0716 Structure source: AlphaFold UniProt Q9I5L2

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Amino acids 441

Annotations 3

Features 14

PDB binders 0

Druggability 0.454

Overview

Basic information about this protein and its source genome.

Accession: PA0716
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0716
Status: annotated
Amino acids: 441
Structure source: AlphaFold

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.454

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
175	248	Pfam	PF13304	AAA domain, putative AbiEii toxin, Type IV TA system
175	248	InterPro	IPR003959	ATPase, AAA-type, core
5	46	Pfam	PF13476	AAA domain
5	46	InterPro	IPR038729	Rad50/SbcC-type AAA domain
142	269	Gene3D	G3DSA:3.40.50.300	-
142	269	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
5	268	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
5	268	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
440	441	Coils	Coil	Coil
4	400	PANTHER	PTHR43581	ATP/GTP PHOSPHATASE
4	101	Gene3D	G3DSA:3.40.50.300	-
4	101	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
24	263	SMART	SM00382	AAA_5
24	263	InterPro	IPR003593	AAA+ ATPase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0716	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.454