Protein profile

PA0732

hypothetical protein

Genome: NC_002516.2

Gene: PA0732 Structure source: AlphaFold UniProt Q9I5J7
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Amino acids 347
Annotations 5
Features 21
PDB binders 1
Druggability 0.884

Overview

Basic information about this protein and its source genome.

Accession
PA0732
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0732
Status
annotated
Amino acids
347
Structure source
AlphaFold
GO
GO:0071972 Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0018104 The process of covalently linking peptidoglycan (murein) to proteins. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.884
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0071972 Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine.
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0018104 The process of covalently linking peptidoglycan (murein) to proteins.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
60 167 CDD cd16913 YkuD_like
60 167 InterPro IPR005490 L,D-transpeptidase catalytic domain
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
59 167 Pfam PF03734 L,D-transpeptidase catalytic domain
59 167 InterPro IPR005490 L,D-transpeptidase catalytic domain
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
216 316 CDD cd16913 YkuD_like
216 316 InterPro IPR005490 L,D-transpeptidase catalytic domain
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 339 PIRSF PIRSF029342 UCP029342_Bll4150
1 339 InterPro IPR016915 Uncharacterised conserved protein UCP029342
55 166 SUPERFAMILY SSF141523 L,D-transpeptidase catalytic domain-like
55 166 InterPro IPR038063 L,D-transpeptidase catalytic domain-like
58 179 Gene3D G3DSA:2.40.440.10 -
58 179 InterPro IPR038063 L,D-transpeptidase catalytic domain-like
185 257 PANTHER PTHR30582 L,D-TRANSPEPTIDASE
58 176 FunFam G3DSA:2.40.440.10:FF:000006 L,D-transpeptidase catalytic domain
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
20 347 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0732
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.884
9 0.284

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

11 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
1RG
3ZGP
Q3Y185 477.5 Da LogP 0.89 TPSA 165.1 1 viol. ✓ Clean C[C@@H]1[C@@H](NC(=C1S[C@H]2C[C@H](NC2)C(=O)Nc3…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.