Protein profile

PA0760

hypothetical protein

Genome: NC_002516.2

Gene: sdhE PA0760 Structure source: AlphaFold UniProt Q9I5G9
Export view
Amino acids 84
Annotations 3
Features 8
PDB binders 0
Druggability 0.429

Overview

Basic information about this protein and its source genome.

Accession
PA0760
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
sdhE PA0760
Status
annotated
Amino acids
84
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552 The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105 The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.429
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0034552 The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II.
  • GO:0006105 The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
3 79 SUPERFAMILY SSF109910 YgfY-like
3 79 InterPro IPR036714 Flavinator of succinate dehydrogenase superfamily
1 83 Gene3D G3DSA:1.10.150.250 Flavinator of succinate dehydrogenase
1 83 InterPro IPR036714 Flavinator of succinate dehydrogenase superfamily
1 82 PANTHER PTHR39585 FAD ASSEMBLY FACTOR SDHE
2 84 FunFam G3DSA:1.10.150.250:FF:000001 FAD assembly factor SdhE
8 79 Pfam PF03937 Flavinator of succinate dehydrogenase
8 79 InterPro IPR005631 Flavinator of succinate dehydrogenase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0760
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.429
1 0.204