Protein profile

PA0763

sigma factor AlgU negative regulator MucA

Genome: NC_002516.2

Gene: PA0763 mucA Structure source: Experimental + AlphaFold UniProt P38107
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Amino acids 194
Annotations 4
Features 14
PDB binders 1
Druggability 0.928

Overview

Basic information about this protein and its source genome.

Accession
PA0763
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0763 mucA
Status
annotated
Amino acids
194
Structure source
Experimental + AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). GO:0032885 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.928
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
  • GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
  • GO:0032885 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 85 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
107 194 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 72 SUPERFAMILY SSF89069 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
6 72 InterPro IPR036147 Anti sigma-E protein RseA, N-terminal domain superfamily
7 57 CDD cd16328 RseA_N
7 57 InterPro IPR005572 Anti sigma-E protein RseA, N-terminal
6 72 FunFam G3DSA:1.10.10.880:FF:000002 Sigma factor AlgU regulatory protein MucA
6 72 Gene3D G3DSA:1.10.10.880 -
86 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 75 Pfam PF03872 Anti sigma-E protein RseA, N-terminal domain
7 75 InterPro IPR005572 Anti sigma-E protein RseA, N-terminal
124 175 Pfam PF03873 Anti sigma-E protein RseA, C-terminal domain
124 175 InterPro IPR005573 Anti sigma-E protein RseA, C-terminal
1 193 PANTHER PTHR38104 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6IN9
X-ray 1.80 Å C,D
45.9% 106-194
PDBe RCSB PDBj File
Viewing
PDB 6JAU
X-ray 1.91 Å B
45.9% 106-194
PDBe RCSB PDBj File
Loaded
PDB 6IN7
X-ray 1.96 Å A
41.2% 1-80
PDBe RCSB PDBj File
Loaded
PDB 8Z6G
X-ray 2.10 Å A,C,E
41.2% 1-80
PDBe RCSB PDBj File
Loaded
AlphaFold PA0763
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.27 0.552
2 4.79 0.212

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

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Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
NCA
6IN7 1.96 Å Open crystal
122.1 Da LogP 0.18 TPSA 56.0 ✓ Ro5 ✓ Clean c1cc(cnc1)C(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.