Protein profile

PA0765

positive regulator for alginate biosynthesis MucC

Genome: NC_002516.2

Gene: mucC PA0765 PAERUG_P19_London_7_VIM_2_05_10_02249 GNQ48_23035 CAZ10_12500 L4V69_28485 IPC1295_12650 Structure source: AlphaFold UniProt G3XCY1 UniProt Q57429
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Amino acids 151
Annotations 3
Features 12
PDB binders 0
Druggability 0.885

Overview

Basic information about this protein and its source genome.

Accession
PA0765
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
mucC PA0765 PAERUG_P19_London_7_VIM_2_05_10_02249 GNQ48_23035 CAZ10_12500 L4V69_28485 IPC1295_12650
Status
annotated
Amino acids
151
Structure source
AlphaFold
GO
GO:1990204 Any protein complex that possesses oxidoreductase activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0032885 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.885
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:1990204 Any protein complex that possesses oxidoreductase activity.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0032885 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 96 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 146 PANTHER PTHR35867 PROTEIN RSEC
1 146 InterPro IPR007359 Positive regulator of sigma(E), RseC/MucC
74 96 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 150 PIRSF PIRSF004923 RseC
1 150 InterPro IPR026268 Protein RseC
102 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 101 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 73 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
123 151 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 141 Pfam PF04246 Positive regulator of sigma(E), RseC/MucC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0765
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.885
4 0.257