Protein profile

PA0770

ribonuclease III

Genome: NC_002516.2

Gene: PA0770 rnc Structure source: AlphaFold UniProt Q9XCX9
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Amino acids 229
Annotations 12
Features 29
PDB binders 0
Druggability 0.663

Overview

Basic information about this protein and its source genome.

Accession
PA0770
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0770 rnc
Status
annotated
Amino acids
229
Structure source
AlphaFold
EC
3.1.26.3
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003725 Binding to double-stranded RNA. GO:0046872 Binding to a metal ion. GO:0004525 Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. GO:0019843 Binding to a ribosomal RNA. GO:0006397 Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.294
Human E-value
1.18e-10
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.663
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSNSLDRLERKLGYTFKDRDLMVLALTHRSYAGRNNERLEFLGDAILNFVIGEALFHHFPQAREGQLSRLRARLVKGETLALLARGFEVGDYLRLGSGELKSGGFRRESILADAMEALIGAIYLDTGMDSARERIIAWLGPQLRELTPVDTNKDPKTRLQEFLQSRGCDLPRYEVVDIQGEPHCRTFFVDCEVALLSDKTHGHGGSRRIAEQVAAAAALVALGVENGHD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 11 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

11
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003725 Binding to double-stranded RNA.
  • GO:0046872 Binding to a metal ion.
  • GO:0004525 Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
  • GO:0019843 Binding to a ribosomal RNA.
  • GO:0006397 Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
  • GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
  • GO:0006396 Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
154 224 ProSiteProfiles PS50137 Double stranded RNA-binding domain (dsRBD) profile.
154 224 InterPro IPR014720 Double-stranded RNA-binding domain
155 223 SMART SM00358 DRBM_3
155 223 InterPro IPR014720 Double-stranded RNA-binding domain
37 45 ProSitePatterns PS00517 Ribonuclease III family signature.
37 45 InterPro IPR000999 Ribonuclease III domain
4 158 SUPERFAMILY SSF69065 RNase III domain-like
4 158 InterPro IPR036389 Ribonuclease III, endonuclease domain superfamily
155 219 Pfam PF00035 Double-stranded RNA binding motif
155 219 InterPro IPR014720 Double-stranded RNA-binding domain
5 127 ProSiteProfiles PS50142 Ribonuclease III family domain profile.
5 127 InterPro IPR000999 Ribonuclease III domain
153 223 Gene3D G3DSA:3.30.160.20 -
18 139 Pfam PF14622 Ribonuclease-III-like
18 139 InterPro IPR000999 Ribonuclease III domain
108 226 SUPERFAMILY SSF54768 dsRNA-binding domain-like
153 212 CDD cd10845 DSRM_RNAse_III_family
20 148 SMART SM00535 riboneu5
20 148 InterPro IPR000999 Ribonuclease III domain
20 148 CDD cd00593 RIBOc
2 147 FunFam G3DSA:1.10.1520.10:FF:000001 Ribonuclease 3
8 220 NCBIfam TIGR02191 ribonuclease III
8 220 InterPro IPR011907 Ribonuclease III
1 145 Gene3D G3DSA:1.10.1520.10 Ribonuclease III domain
1 145 InterPro IPR036389 Ribonuclease III, endonuclease domain superfamily
2 222 PANTHER PTHR14950 DICER-RELATED
8 219 Hamap MF_00104 Ribonuclease 3 [rnc].
8 219 InterPro IPR011907 Ribonuclease III
153 223 FunFam G3DSA:3.30.160.20:FF:000077 Ribonuclease 3

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0770
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.663
5 0.312