Protein profile

PA0778

inhibitor of cysteine peptidase

Genome: NC_002516.2

Gene: PA0778 icp Structure source: AlphaFold UniProt Q9I5G0
Export view
Amino acids 134
Annotations 2
Features 16
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
PA0778
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0778 icp
Status
annotated
Amino acids
134
Structure source
AlphaFold
GO
GO:0004869 Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. GO:0030162 Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004869 Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase.
  • GO:0030162 Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
23 134 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
32 133 SUPERFAMILY SSF141066 ICP-like
32 133 InterPro IPR036331 Chagasin-like superfamily
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
41 129 Pfam PF09394 Chagasin family peptidase inhibitor I42
41 129 InterPro IPR018990 Proteinase inhibitor I42, chagasin
38 134 Gene3D G3DSA:2.60.40.2020 -
38 134 InterPro IPR036331 Chagasin-like superfamily
6 133 PANTHER PTHR36530 INHIBITOR OF CYSTEINE PEPTIDASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model PA0778 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0778
AlphaFold — — full sequence — Viewing