Protein profile

PA0787

hypothetical protein

Genome: NC_002516.2

Gene: PA0787 Structure source: AlphaFold UniProt Q9I5F1
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Amino acids 387
Annotations 4
Features 13
PDB binders 0
Druggability 0.82

Overview

Basic information about this protein and its source genome.

Accession
PA0787
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0787
Status
annotated
Amino acids
387
Structure source
AlphaFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.82
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
  • GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
23 348 InterPro IPR003959 ATPase, AAA-type, core
227 372 Gene3D G3DSA:3.40.50.300 -
227 372 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 69 Gene3D G3DSA:3.40.50.300 -
1 69 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 69 FunFam G3DSA:3.40.50.300:FF:002708 FeS assembly ATPase SufC
23 348 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system
1 353 PANTHER PTHR32182 DNA REPLICATION AND REPAIR PROTEIN RECF
221 372 FunFam G3DSA:3.40.50.300:FF:002534 Putative RecF protein
1 387 PIRSF PIRSF029347 RecF
1 387 InterPro IPR014555 RecF-like
1 350 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 350 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0787
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.82
6 0.333