Protein profile

PA0812

hypothetical protein

Genome: NC_002516.2

Gene: PA0812 Structure source: AlphaFold UniProt Q9I5C7
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Amino acids 431
Annotations 2
Features 7
PDB binders 0
Druggability 0.751

Overview

Basic information about this protein and its source genome.

Accession
PA0812
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0812
Status
annotated
Amino acids
431
Structure source
AlphaFold
GO
GO:0043720 Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.751
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTGSRKTLILGCASTGAKFTPRNHAATGDRLLDSICTGATIRTAPGELLDEARQLYEMGCRYYHYHARNPLTQEQTTDNDIYQAVSRALQNRFPDLMLSFGASRNGSEVQENIRRFGEWERVSHCAIPLHLGGAHFVTIQAAIELQVICELEKQRRKLDLDYASSPAFLADLRDYQPSTALEKAELQTHSTSKGADYGVTSPMTQFQVYRNAIQARQKLGLFHEVEWVQHVRSYAMTRFAVEHPRLRLGDSGQLNVILLFGFSPRLPFPETYQQFRAVIESAKSLEYDIGEPCVRKRKVSITVGAAVMPQHAAQHFRPLDVGPRAGTPLCAVRRLAAYAAQADSQVDVLRVGMEDTPYAVDDDGRVTLSDNCQLLRQALDELRANGAEAELDGERIFQRMGMERTLGEYLSLQRLHPLGEANFTLAREFVQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0043720 Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
2 391 Gene3D G3DSA:3.20.20.70 Aldolase class I
2 391 InterPro IPR013785 Aldolase-type TIM barrel
1 405 PANTHER PTHR37418 3-KETO-5-AMINOHEXANOATE CLEAVAGE ENZYME-RELATED
1 405 InterPro IPR008567 Beta-keto acid cleavage enzymes
44 136 Pfam PF05853 beta-keto acid cleavage enzyme
44 136 InterPro IPR008567 Beta-keto acid cleavage enzymes
365 392 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0812
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.751
9 0.295
3 0.234