Protein profile

PA0817

ring-cleaving dioxygenase

Genome: NC_002516.2

Gene: PA0817 Structure source: AlphaFold UniProt Q9I5C2

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Amino acids 141

Annotations 1

Features 10

PDB binders 0

Druggability 0.85

Overview

Basic information about this protein and its source genome.

Accession: PA0817
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0817
Status: annotated
Amino acids: 141
Structure source: AlphaFold

GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.85

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
6	132	CDD	cd08357	VOC_like
7	129	Pfam	PF00903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
7	129	InterPro	IPR004360	Glyoxalase/fosfomycin resistance/dioxygenase domain
3	138	Gene3D	G3DSA:3.10.180.10	-
3	138	InterPro	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
4	132	ProSiteProfiles	PS51819	Vicinal oxygen chelate (VOC) domain profile.
4	132	InterPro	IPR037523	Vicinal oxygen chelate (VOC) domain
2	141	PANTHER	PTHR39434	-
6	131	SUPERFAMILY	SSF54593	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
6	131	InterPro	IPR029068	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0817	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.85