Protein profile

PA0820

hypothetical protein

Genome: NC_002516.2

Gene: PA0820 Structure source: AlphaFold UniProt Q9I5B9
Export view
Amino acids 270
Annotations 3
Features 4
PDB binders 0
Druggability 0.661

Overview

Basic information about this protein and its source genome.

Accession
PA0820
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0820
Status
annotated
Amino acids
270
Structure source
AlphaFold
GO
GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003676 Binding to a nucleic acid. GO:0008270 Binding to a zinc ion (Zn).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.661
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPAVIAENDVSIWDDETGAVYHYPRRYSAILKPGVQVVYYKGKLTDKSFADQRLSAQPHYFGIARIGKVYPDPESSKGDLFALIESFQPFEQAVLAKEGNSYLEPIPPSKASNYWRSGVREIGQVTFDSILARAEIKPLQVAESWGDRALGGFESRTEGSLSTYYGVRYERDPTLRLQAIAIHGVACKACGFDFGKAYGEYAKGFIHVHHTQPISEFEAPKAVNPETDLVPLCANCHAVVHRRRDRTLSVDELKGLVRGRWVCAEADVVV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008270 Binding to a zinc ion (Zn).

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
187 242 Pfam PF01844 HNH endonuclease
187 242 InterPro IPR002711 HNH endonuclease
175 241 CDD cd00085 HNHc
175 241 InterPro IPR003615 HNH nuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0820
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.661
2 0.367