Protein profile

PA0834

acyltransferase

Genome: NC_002516.2

Gene: PA0834 Structure source: AlphaFold UniProt Q9I5A6
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Amino acids 304
Annotations 1
Features 13
PDB binders 0
Druggability 0.94

Overview

Basic information about this protein and its source genome.

Accession
PA0834
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0834
Status
annotated
Amino acids
304
Structure source
AlphaFold
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.316
Human E-value
4.27e-09
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.94
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
12 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 116 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 221 Pfam PF01553 Acyltransferase
76 221 InterPro IPR002123 Phospholipid/glycerol acyltransferase
58 288 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 299 PANTHER PTHR10983 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED
117 136 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
89 231 SMART SM00563 plsc_2
89 231 InterPro IPR002123 Phospholipid/glycerol acyltransferase
88 253 CDD cd07990 LPLAT_LCLAT1-like
137 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0834
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.94
2 0.283