Protein profile

PA0858

hypothetical protein

Genome: NC_002516.2

Gene: trhO PA0858 Structure source: AlphaFold UniProt Q9I583
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Amino acids 312
Annotations 3
Features 20
PDB binders 0
Druggability 0.602

Overview

Basic information about this protein and its source genome.

Accession
PA0858
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
trhO PA0858
Status
annotated
Amino acids
312
Structure source
AlphaFold
EC
1.14.-.-
GO
GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0006400 The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.091
Human E-value
3.2900000000000004e-32
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.602
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
  • GO:0006400 The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
97 251 Gene3D G3DSA:3.40.250.10 -
97 251 InterPro IPR036873 Rhodanese-like domain superfamily
3 280 PANTHER PTHR43268 THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2
3 280 InterPro IPR020936 tRNA uridine(34) hydroxylase
282 300 MobiDBLite mobidb-lite consensus disorder prediction
90 225 SUPERFAMILY SSF52821 Rhodanese/Cell cycle control phosphatase
90 225 InterPro IPR036873 Rhodanese-like domain superfamily
5 95 Pfam PF17773 UPF0176 acylphosphatase like domain
5 95 InterPro IPR040503 tRNA uridine(34) hydroxylase, N-terminal
110 210 CDD cd01518 RHOD_YceA
1 96 Gene3D G3DSA:3.30.70.100 -
115 210 Pfam PF00581 Rhodanese-like domain
115 210 InterPro IPR001763 Rhodanese-like domain
123 217 ProSiteProfiles PS50206 Rhodanese domain profile.
123 217 InterPro IPR001763 Rhodanese-like domain
113 214 SMART SM00450 rhod_4
113 214 InterPro IPR001763 Rhodanese-like domain
2 254 Hamap MF_00469 tRNA uridine(34) hydroxylase [trhO].
2 254 InterPro IPR020936 tRNA uridine(34) hydroxylase
282 312 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0858
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.602