Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0864
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0864
Status: annotated
Amino acids: 262
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.93

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
172	253	SMART	SM00342	aracneu4
172	253	InterPro	IPR018060	DNA binding HTH domain, AraC-type
5	258	PANTHER	PTHR11019	HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
9	97	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
9	97	InterPro	IPR014710	RmlC-like jelly roll fold
14	177	SUPERFAMILY	SSF51182	RmlC-like cupins
14	177	InterPro	IPR011051	RmlC-like cupin domain superfamily
207	249	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
207	249	InterPro	IPR018062	HTH domain AraC-type, conserved site
178	254	Pfam	PF12833	Helix-turn-helix domain
178	254	InterPro	IPR018060	DNA binding HTH domain, AraC-type
210	257	SUPERFAMILY	SSF46689	Homeodomain-like
210	257	InterPro	IPR009057	Homeobox-like domain superfamily
152	260	Gene3D	G3DSA:1.10.10.60	-
16	110	CDD	cd06124	cupin_NimR-like_N
153	256	FunFam	G3DSA:1.10.10.60:FF:000132	AraC family transcriptional regulator
24	109	Pfam	PF02311	AraC-like ligand binding domain
24	109	InterPro	IPR003313	AraC-type arabinose-binding/dimerisation domain
156	255	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
156	255	InterPro	IPR018060	DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0864	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.93
9				0.289

PA0864