Protein profile

PA0867

lysozyme inhibitor

Genome: NC_002516.2

Gene: PA0867 mliC Structure source: Experimental + AlphaFold UniProt Q9I574
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Amino acids 127
Annotations 1
Features 15
PDB binders 0
Druggability 0.949

Overview

Basic information about this protein and its source genome.

Accession
PA0867
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0867 mliC
Status
annotated
Amino acids
127
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.949
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
43 117 SUPERFAMILY SSF141488 YdhA-like
43 117 InterPro IPR036328 C-type lysozyme inhibitor superfamily
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
41 127 Gene3D G3DSA:2.40.128.200 -
41 127 InterPro IPR036328 C-type lysozyme inhibitor superfamily
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
49 114 Pfam PF09864 Membrane-bound lysozyme-inhibitor of c-type lysozyme
49 114 InterPro IPR018660 C-type lysozyme inhibitor
4 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 18 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
21 127 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
17 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3F6Z
X-ray 2.50 Å B,D
78.0% 29-127
PDBe RCSB PDBj File
Viewing
AlphaFold PA0867
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.51 0.07
2 0.85 0.003