Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0868
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0868
Status: annotated
Amino acids: 137
Structure source: AlphaFold

EC

3.1.1.29

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004045 Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+. GO:0043022 Binding to a ribosome. GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. GO:0072344 A process of cytosolic translational elongation that takes place when a cytosolic ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 26.733
Human E-value: 5.29e-07
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.79

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

3.1.1.29

Gene Ontology (GO)

7

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0004045 Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+.
GO:0043022 Binding to a ribosome.
GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
GO:0072344 A process of cytosolic translational elongation that takes place when a cytosolic ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex.
GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
113	137	MobiDBLite	mobidb-lite	consensus disorder prediction
1	136	PANTHER	PTHR47814	PEPTIDYL-TRNA HYDROLASE ARFB
8	117	SUPERFAMILY	SSF75620	Release factor
8	117	InterPro	IPR045853	Peptide chain release factor class I superfamily
1	137	FunFam	G3DSA:3.30.160.20:FF:000029	Peptidyl-tRNA hydrolase YaeJ
8	132	Pfam	PF00472	RF-1 domain
8	132	InterPro	IPR000352	Peptide chain release factor class I
1	136	Gene3D	G3DSA:3.30.160.20	-
77	104	Coils	Coil	Coil
21	37	ProSitePatterns	PS00745	Prokaryotic-type class I peptide chain release factors signature.
21	37	InterPro	IPR000352	Peptide chain release factor class I
101	137	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0868	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.79
2				0.564

PA0868