Protein profile

PA0878

hypothetical protein

Genome: NC_002516.2

Gene: PA0878 Structure source: AlphaFold UniProt Q9I567
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Amino acids 275
Annotations 1
Features 10
PDB binders 0
Druggability 0.73

Overview

Basic information about this protein and its source genome.

Accession
PA0878
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0878
Status
annotated
Amino acids
275
Structure source
AlphaFold
GO
GO:0019171 Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.73
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSESAFAPWIGRQEETHDQLSRNLVKRIAATFGEPTPAHGEALPPLWHWAFFQDPVEAAGLGVDGHPARGGFLPPADDRNRMWAGGRLEFHQPLRVGGEASRTSTILRVEEKHGRSGALLFVTLRHDYRQDGQLALSEEHDIVYREPTPPKLGGTEALPEGDWREALEPDPVLLFRYSAVTFNGHRIHYDWPYVTDAEGYPGLVVHGPLIATLALRAFCRANPQARLRRFAYRGLRPLICPEPFEVGGRLLAAGKAEVWVGNGAGLAQRGDVEFD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019171 Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
168 260 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
168 260 InterPro IPR029069 HotDog domain superfamily
164 274 FunFam G3DSA:3.10.129.10:FF:000127 Itaconyl-CoA hydratase
164 274 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
3 274 PANTHER PTHR28152 HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL
61 133 Pfam PF13452 N-terminal half of MaoC dehydratase
61 133 InterPro IPR039569 N-terminal of MaoC-like dehydratase
10 151 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
58 147 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
58 147 InterPro IPR029069 HotDog domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0878
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.73
1 0.643
2 0.489