Protein profile

PA0888

arginine/ornithine ABC transporter substrate-binding protein AotJ

Genome: NC_002516.2

Gene: CAZ10_11855 GUL26_29090 IPC1295_28105 argT_2 aotJ PA0888 GNQ48_18370 L4V69_26825 PAERUG_P19_London_7_VIM_2_05_10_01030 DT376_25980 Structure source: AlphaFold UniProt G3XD47 UniProt O50181
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Amino acids 259
Annotations 5
Features 21
PDB binders 8
Druggability 0.659

Overview

Basic information about this protein and its source genome.

Accession
PA0888
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
CAZ10_11855 GUL26_29090 IPC1295_28105 argT_2 aotJ PA0888 GNQ48_18370 L4V69_26825 PAERUG_P19_London_7_VIM_2_05_10_01030 DT376_25980
Status
annotated
Amino acids
259
Structure source
AlphaFold
GO
GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.659
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MKKLALLGALALSVLSLPTFAADKPVRIGIEAAYPPFSLKTPDGQLAGFDVDIGNALCEEMKVQCKWVEQEFDGLIPALKVRKIDAILSSMTITDERKRSVDFTNKYYNTPARFVMKEGASLNDPKADLKGKKAGVLRGSTADRYASAELTPAGVEVVRYNSQQEANMDLVAGRLDAVVADSVNLEDGFLKTDAGKGYAFVGPQLTDAKYFGEGVGIAVRKGDSELAGKFNAAIDALRANGKYKQIQDKYFSFDVYGSN

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0016597 Binding to an amino acid, organic acids containing one or more amino substituents.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0071705 The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
25 254 SMART SM00062 AABind_6
25 254 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
22 259 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
111 211 Gene3D G3DSA:3.40.190.10 -
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
48 61 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
48 61 InterPro IPR018313 Solute-binding protein family 3, conserved site
5 251 PANTHER PTHR35936 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
27 250 Gene3D G3DSA:3.40.190.10 -
111 211 FunFam G3DSA:3.40.190.10:FF:000245 ABC transporter substrate-binding protein
4 251 NCBIfam TIGR01096 lysine/arginine/ornithine ABC transporter substrate-binding protein
4 251 InterPro IPR005768 Specific amino acids and opine-binding periplasmic protein, ABC transporter
1 255 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
26 252 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3
26 252 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
24 251 CDD cd13703 PBP2_HisJ_LAO
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0888
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.62
3 0.264

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2W2
5OVZ
P35120 304.3 Da LogP -1.39 TPSA 185.8 1 viol. ✓ Clean [H]/N=C(/N)\NCCC[C@@H](C(=O)O)N[C@H](CCC(=O)O)C…
6DB
5ITO
P35120 246.3 Da LogP -1.23 TPSA 148.5 1 viol. ✓ Clean [H]/N=C(/N)\NCCC[C@@H](C(=O)O)N[C@H](C)C(=O)O
AOZ
5OT9
P35120 227.2 Da LogP -0.53 TPSA 115.3 ✓ Ro5 ✓ Clean CC(C(=O)O)NC(Cc1c[nH]cn1)C(=O)O
AQK
5OTC
P35120 190.2 Da LogP -1.15 TPSA 112.7 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)NCC(=O)O)CN
AQQ
5OTA
P35120 204.2 Da LogP -0.76 TPSA 112.6 ✓ Ro5 ✓ Clean C[C@H](C(=O)O)N[C@@H](CCCN)C(=O)O
OP1
4POW
P35120 286.3 Da LogP -1.22 TPSA 156.8 ✓ Ro5 ✓ Clean [H]/N=C(\N)/NCCC[C@@H](C(=O)O)N1[C@H](CCC1=O)C(…
ORN
1LAH
P02911 132.2 Da LogP -0.86 TPSA 89.3 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)CN
TOE
5ITO
P35120 164.2 Da LogP -0.34 TPSA 47.9 ✓ Ro5 ✓ Clean COCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.