Protein profile

PA0893

transcriptional regulator ArgR

Genome: NC_002516.2

Gene: CAZ10_11830 PAERUG_P19_London_7_VIM_2_05_10_01035 IPC1295_28080 cdhR_3 L4V69_26800 argR PA0893 ALP65_00194 Structure source: AlphaFold UniProt G3XCU2 UniProt O30507
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Amino acids 329
Annotations 10
Features 31
PDB binders 0
Druggability 0.504

Overview

Basic information about this protein and its source genome.

Accession
PA0893
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
CAZ10_11830 PAERUG_P19_London_7_VIM_2_05_10_01035 IPC1295_28080 cdhR_3 L4V69_26800 argR PA0893 ALP65_00194
Status
annotated
Amino acids
329
Structure source
AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:1900079 Any process that modulates the frequency, rate or extent of arginine biosynthetic process.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.504
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:1900079 Any process that modulates the frequency, rate or extent of arginine biosynthetic process.
  • GO:1900081 Any process that modulates the frequency, rate or extent of arginine catabolic process.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
294 310 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
294 310 InterPro IPR020449 Transcription regulator HTH, AraC- type
279 294 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
279 294 InterPro IPR020449 Transcription regulator HTH, AraC- type
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
164 314 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
207 312 FunFam G3DSA:1.10.10.60:FF:000090 Transcriptional regulator ArgR, AraC family
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
2 200 FunFam G3DSA:3.40.50.880:FF:000074 Transcriptional regulator ArgR
263 314 SUPERFAMILY SSF46689 Homeodomain-like
263 314 InterPro IPR009057 Homeobox-like domain superfamily
214 312 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
214 312 InterPro IPR018060 DNA binding HTH domain, AraC-type
2 200 Gene3D G3DSA:3.40.50.880 -
2 200 InterPro IPR029062 Class I glutamine amidotransferase-like
25 329 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 SignalP_EUK SignalP-noTM SignalP-noTM
210 261 SUPERFAMILY SSF46689 Homeodomain-like
210 261 InterPro IPR009057 Homeobox-like domain superfamily
5 192 SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like
5 192 InterPro IPR029062 Class I glutamine amidotransferase-like
207 315 Gene3D G3DSA:1.10.10.60 -
233 311 Pfam PF12833 Helix-turn-helix domain
233 311 InterPro IPR018060 DNA binding HTH domain, AraC-type
8 189 CDD cd03136 GATase1_AraC_ArgR_like
264 306 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
264 306 InterPro IPR018062 HTH domain AraC-type, conserved site
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
227 310 SMART SM00342 aracneu4
227 310 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0893
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.504
12 0.35
2 0.222