Protein profile

PA0896

arginine N-succinyltransferase subunit alpha

Genome: NC_002516.2

Gene: astA PA0896 aruF Structure source: Experimental + AlphaFold UniProt P80357
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Amino acids 338
Annotations 5
Features 10
PDB binders 0
Druggability 0.685

Overview

Basic information about this protein and its source genome.

Accession
PA0896
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
astA PA0896 aruF
Status
annotated
Amino acids
338
Structure source
Experimental + AlphaFold
EC
2.3.1.109
GO
GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015 Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.685
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MLVMRPAQAADLPQVQRLAADSPVGVTSLPDDAERLRDKILASEASFAAEVSYNGEESYFFVLEDSASGELVGCSAIVASAGFSEPFYSFRNETFVHASRSLSIHNKIHVLSLCHDLTGNSLLTSFYVQRDLVQSVYAELNSRGRLLFMASHPERFADAVVVEIVGYSDEQGESPFWNAVGRNFFDLNYIEAEKLSGLKSRTFLAELMPHYPIYVPLLPDAAQESMGQVHPRAQITFDILMREGFETDNYIDIFDGGPTLHARTSGIRSIAQSRVVPVKIGEAPKSGRPYLVTNGQLQDFRAVVLDLDWAPGKPVALSVEAAEALGVGEGASVRLVAV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.
  • GO:0009015 Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4.
  • GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.
  • GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 337 PANTHER PTHR30420 N-SUCCINYLARGININE DIHYDROLASE
3 337 NCBIfam TIGR03243 arginine and ornithine succinyltransferase subunits
3 337 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
1 337 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 337 InterPro IPR016181 Acyl-CoA N-acyltransferase
274 338 Gene3D G3DSA:2.40.40.20 -
1 336 Pfam PF04958 Arginine N-succinyltransferase beta subunit
1 336 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
3 338 NCBIfam TIGR03245 arginine/ornithine succinyltransferase subunit alpha
3 338 InterPro IPR017651 Arginine/ornithine succinyltransferase, alpha subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1YLE
X-ray 1.70 Å A
100.0% 1-338
PDBe RCSB PDBj File
Viewing
AlphaFold PA0896
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.685
4 0.377

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.3 0.912
2 5.91 0.289
3 4.62 0.2
4 3.39 0.122
5 1.8 0.034