Protein profile

PA0897

arginine N-succinyltransferase subunit beta

Genome: NC_002516.2

Gene: PA0897 aruG Structure source: AlphaFold UniProt P80358
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Amino acids 340
Annotations 5
Features 10
PDB binders 0
Druggability 0.728

Overview

Basic information about this protein and its source genome.

Accession
PA0897
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0897 aruG
Status
annotated
Amino acids
340
Structure source
AlphaFold
EC
2.3.1.109
GO
GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015 Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.728
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MIVRPVTSADLPALIELARSTGTGLTTLPANEQRLQHRVSWAEKAFRGEAERGDADYLFVLEDDAGKVVGISAIAGAVGLREPWYNYRVGLTVSASQELNIHREIPTLFLANDLTGNSELCSLFLHADHRSGLNGKLLSRARFLFIAEFRHLFGDKLIAEMRGMSDEEGRSPFWESLGRHFFKMEFSQADYLTGVGNKAFIAELMPKFPLYTCFLSEEARGVIGRVHPNTEPALAMLKAEGFSYQGYVDIFDAGPAIEAETDKIRAIAESQNLVLAVGTPGDDAEPYLIHNRKREDCRITAAPARAAAGTLVVDPLTAKRLRLSAGASVRAVPLSAQKRG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.
  • GO:0009015 Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4.
  • GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.
  • GO:0019545 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including succinate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 334 PANTHER PTHR30420 N-SUCCINYLARGININE DIHYDROLASE
1 332 Pfam PF04958 Arginine N-succinyltransferase beta subunit
1 332 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
2 334 NCBIfam TIGR03244 arginine N-succinyltransferase
2 334 InterPro IPR017650 Arginine N-succinyltransferase
2 334 NCBIfam TIGR03243 arginine and ornithine succinyltransferase subunits
2 334 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
1 334 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 334 InterPro IPR016181 Acyl-CoA N-acyltransferase
1 178 Gene3D G3DSA:3.40.630.30 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0897
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.728
5 0.637