Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0906
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0906
Status: annotated
Amino acids: 237
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001896 A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.455

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0001896 A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation.
GO:0006974 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
103	235	FunFam	G3DSA:2.10.109.10:FF:000016	HTH-type transcriptional regulator prtR
101	233	SUPERFAMILY	SSF51306	LexA/Signal peptidase
101	233	InterPro	IPR036286	LexA/Signal peptidase-like superfamily
1	68	Gene3D	G3DSA:1.10.260.40	-
1	68	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
6	60	SMART	SM00530	mbf_short4
6	60	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
3	61	SUPERFAMILY	SSF47413	lambda repressor-like DNA-binding domains
3	61	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
7	60	Pfam	PF01381	Helix-turn-helix
7	60	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
5	60	CDD	cd00093	HTH_XRE
5	60	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
109	231	Pfam	PF00717	Peptidase S24-like
109	231	InterPro	IPR015927	Peptidase S24/S26A/S26B/S26C
146	228	CDD	cd06529	S24_LexA-like
146	228	InterPro	IPR039418	LexA-like
2	236	PANTHER	PTHR40661	-
109	235	Gene3D	G3DSA:2.10.109.10	Umud Fragment, subunit A
7	60	ProSiteProfiles	PS50943	Cro/C1-type HTH domain profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0906	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.455
4				0.364

PA0906