Protein profile

PA0935

nucleoside triphosphate pyrophosphohydrolase

Genome: NC_002516.2

Gene: PA0935 Structure source: AlphaFold UniProt Q9I523
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Amino acids 276
Annotations 10
Features 16
PDB binders 0
Druggability 0.763

Overview

Basic information about this protein and its source genome.

Accession
PA0935
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA0935
Status
annotated
Amino acids
276
Structure source
AlphaFold
EC
3.6.1.8
GO
GO:0047693 Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. GO:0047429 Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0046061 The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate). GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. GO:0046076 The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate. GO:0046081 The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.763
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MYRLDDLLHLMARLRDPEFGCPWDLQQSYATIVPHTLEEAYEVADAIEQGDFPQLREELGDLLFQVVYYSQLAREEDRFAFDEVVDGITRKLIRRHPHVFLDGDLYGKPDAAKLAEAAVKQRWEELKAEERAAKAKEPQQLSLLDDVPVALPALSRAAKLQKRAAQVGFDWPEALPVVDKVREGLDEVLEAMAEGDEGAVGEEVGDLLFVVVNLARHLKVDPEAALRQANGKFERRFRFIERNLREAGRKAEECSLEELDSLWGEAKKAERSAPGC

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0047693 Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate.
  • GO:0047429 Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate.
  • GO:0046061 The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate).
  • GO:0006203 The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate.
  • GO:0046076 The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate.
  • GO:0046081 The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
  • GO:0046047 The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate.
  • GO:0046052 The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
141 271 Gene3D G3DSA:1.10.287.1080 -
5 127 CDD cd11528 NTP-PPase_MazG_Nterm
1 133 Gene3D G3DSA:1.10.287.1080 -
2 271 PANTHER PTHR30522 NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE
2 271 InterPro IPR011551 NTP pyrophosphohydrolase MazG
10 267 NCBIfam TIGR00444 MazG family protein
10 267 InterPro IPR011551 NTP pyrophosphohydrolase MazG
147 245 SUPERFAMILY SSF101386 all-alpha NTP pyrophosphatases
27 100 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain
27 100 InterPro IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core
183 236 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain
183 236 InterPro IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core
2 104 SUPERFAMILY SSF101386 all-alpha NTP pyrophosphatases
141 271 FunFam G3DSA:1.10.287.1080:FF:000003 Nucleoside triphosphate pyrophosphohydrolase
1 132 FunFam G3DSA:1.10.287.1080:FF:000001 Nucleoside triphosphate pyrophosphohydrolase
152 267 CDD cd11529 NTP-PPase_MazG_Cterm

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA0935
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.763
2 0.559
8 0.406
6 0.31