Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0942
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0942
Status: annotated
Amino acids: 186
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.47

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0032993 A macromolecular complex containing both protein and DNA molecules.
GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
49	65	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
49	65	InterPro	IPR000835	MarR-type HTH domain
66	81	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
66	81	InterPro	IPR000835	MarR-type HTH domain
85	101	PRINTS	PR00598	Bacterial regulatory protein MarR family signature
85	101	InterPro	IPR000835	MarR-type HTH domain
30	89	Pfam	PF12802	MarR family
30	89	InterPro	IPR000835	MarR-type HTH domain
1	132	FunFam	G3DSA:1.10.10.10:FF:000945	Probable transcriptional regulator
7	138	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
7	138	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
2	132	Gene3D	G3DSA:1.10.10.10	-
2	132	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
23	123	SMART	SM00347	marrlong4
23	123	InterPro	IPR000835	MarR-type HTH domain
3	134	ProSiteProfiles	PS50995	MarR-type HTH domain profile.
3	134	InterPro	IPR000835	MarR-type HTH domain
3	132	PANTHER	PTHR33164	TRANSCRIPTIONAL REGULATOR, MARR FAMILY
3	132	InterPro	IPR039422	Transcription regulators MarR/SlyA-like
64	98	ProSitePatterns	PS01117	MarR-type HTH domain signature.
64	98	InterPro	IPR023187	Transcriptional regulator MarR-type, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0942	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.421
4				0.306
3				0.298

PA0942