Protein profile

PA0949

NAD(P)H dehydrogenase

Genome: NC_002516.2

Gene: wrbA Structure source: ColabFold
Export view
Amino acids 198
Annotations 4
Features 14
PDB binders 3
Druggability 0.498

Overview

Basic information about this protein and its source genome.

Accession
PA0949
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
wrbA
Status
annotated
Amino acids
198
Structure source
ColabFold
GO
GO:0003955 Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.498
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003955 Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
6 196 PANTHER PTHR30546 FLAVODOXIN-RELATED PROTEIN WRBA-RELATED
6 196 NCBIfam TIGR01755 NAD(P)H:quinone oxidoreductase, type IV
6 196 InterPro IPR010089 Flavoprotein WrbA-like
6 190 ProSiteProfiles PS50902 Flavodoxin-like domain profile.
6 190 InterPro IPR008254 Flavodoxin/nitric oxide synthase
1 198 Gene3D G3DSA:3.40.50.360 -
1 198 InterPro IPR029039 Flavoprotein-like superfamily
8 24 ProSitePatterns PS00201 Flavodoxin signature.
8 24 InterPro IPR001226 Flavodoxin, conserved site
1 198 FunFam G3DSA:3.40.50.360:FF:000001 NAD(P)H dehydrogenase (Quinone) FQR1-like
13 141 Pfam PF03358 NADPH-dependent FMN reductase
13 141 InterPro IPR005025 NADPH-dependent FMN reductase-like
4 196 SUPERFAMILY SSF52218 Flavoproteins
4 196 InterPro IPR029039 Flavoprotein-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA0949
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.498
4 0.202

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
15P
3B6I
P0A8G6 1529.8 Da LogP 0.17 TPSA 334.1 2 viol. ✓ Clean COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO…
MHO
4YQE
P0A8G6 165.2 Da LogP -0.83 TPSA 80.4 ✓ Ro5 ✓ Clean C[S@](=O)CC[C@@H](C(=O)O)N
PLQ
3B6K
P0A8G6 108.1 Da LogP 0.25 TPSA 34.1 ✓ Ro5 Alert C1=CC(=O)C=CC1=O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.