Overview
Basic information about this protein and its source genome.
- Accession
- PA0954
- Gene
- PA0954 acyP
- Status
- annotated
- Amino acids
- 91
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 42.857
- Human E-value
- 1.1e-06
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Cytoplasmic
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
1- GO:0003998 Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 10 | 20 | ProSitePatterns | PS00150 | Acylphosphatase signature 1. |
| 10 | 20 | InterPro | IPR017968 | Acylphosphatase, conserved site |
| 1 | 91 | Gene3D | G3DSA:3.30.70.100 | - |
| 7 | 90 | PANTHER | PTHR47268 | ACYLPHOSPHATASE |
| 7 | 90 | InterPro | IPR020456 | Acylphosphatase |
| 7 | 87 | Pfam | PF00708 | Acylphosphatase |
| 7 | 87 | InterPro | IPR001792 | Acylphosphatase-like domain |
| 34 | 50 | ProSitePatterns | PS00151 | Acylphosphatase signature 2. |
| 34 | 50 | InterPro | IPR017968 | Acylphosphatase, conserved site |
| 5 | 91 | ProSiteProfiles | PS51160 | Acylphosphatase-like domain profile. |
| 5 | 91 | InterPro | IPR001792 | Acylphosphatase-like domain |
| 4 | 90 | SUPERFAMILY | SSF54975 | Acylphosphatase/BLUF domain-like |
| 4 | 90 | InterPro | IPR036046 | Acylphosphatase-like domain superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed AlphaFold model PA0954 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA0954
|
AlphaFold | — | — | full sequence | — | Viewing |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| MOO | A5F8G9 | 159.9 Da LogP -2.62 TPSA 80.3 | ✓ Ro5 | ✓ Clean |
[O-][Mo](=O)(=O)[O-]
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.