Protein profile

PA0961

cold-shock protein

Genome: NC_002516.2

Gene: NP_249652.2 Structure source: ColabFold
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Amino acids 204
Annotations 1
Features 36
PDB binders 1
Druggability 0.838

Overview

Basic information about this protein and its source genome.

Accession
PA0961
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
NP_249652.2
Status
annotated
Amino acids
204
Structure source
ColabFold
GO
GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
66.667
Human E-value
4.99e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.838
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records
Show feature table
Start End DB Term Name
53 63 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 204 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
34 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
139 202 SMART SM00357 csp_8
139 202 InterPro IPR011129 Cold shock domain
4 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
4 22 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
138 201 PANTHER PTHR11544 COLD SHOCK DOMAIN CONTAINING PROTEINS
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
137 200 SUPERFAMILY SSF50249 Nucleic acid-binding proteins
137 200 InterPro IPR012340 Nucleic acid-binding, OB-fold
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
62 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
64 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
175 193 PRINTS PR00050 Cold shock protein signature
175 193 InterPro IPR002059 Cold-shock protein, DNA-binding
140 155 PRINTS PR00050 Cold shock protein signature
140 155 InterPro IPR002059 Cold-shock protein, DNA-binding
160 169 PRINTS PR00050 Cold shock protein signature
160 169 InterPro IPR002059 Cold-shock protein, DNA-binding
137 201 ProSiteProfiles PS51857 Cold-shock (CSD) domain profile.
137 201 InterPro IPR002059 Cold-shock protein, DNA-binding
93 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
139 199 CDD cd04458 CSP_CDS
139 199 InterPro IPR002059 Cold-shock protein, DNA-binding
139 200 Pfam PF00313 'Cold-shock' DNA-binding domain
139 200 InterPro IPR002059 Cold-shock protein, DNA-binding
25 33 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
151 169 ProSitePatterns PS00352 Cold-shock (CSD) domain signature.
151 169 InterPro IPR019844 Cold-shock (CSD) domain
130 204 Gene3D G3DSA:2.40.50.140 -
130 204 InterPro IPR012340 Nucleic acid-binding, OB-fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold PA0961
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.838
4 0.783

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

24 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NHE
6T00
P32081 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.