Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0972
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: tolB PA0972
Status: annotated
Amino acids: 432
Structure source: AlphaFold

GO

GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0017038 The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.816

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
GO:0017038 The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records

Show feature table

Start	End	DB	Term	Name
153	429	SUPERFAMILY	SSF69304	Tricorn protease N-terminal domain
24	160	Gene3D	G3DSA:3.40.50.10070	-
25	126	Pfam	PF04052	TolB amino-terminal domain
25	126	InterPro	IPR007195	TolB, N-terminal
15	21	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	21	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
4	427	Hamap	MF_00671	Tol-Pal system protein TolB [tolB].
4	427	InterPro	IPR014167	Tol-Pal system protein TolB
162	432	Gene3D	G3DSA:2.120.10.30	-
162	432	InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
1	21	Phobius	SIGNAL_PEPTIDE	Signal peptide region
22	432	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	21	SignalP_EUK	SignalP-noTM	SignalP-noTM
29	158	SUPERFAMILY	SSF52964	TolB, N-terminal domain
3	14	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
115	400	PANTHER	PTHR36842	PROTEIN TOLB HOMOLOG
197	227	Pfam	PF07676	WD40-like Beta Propeller Repeat
197	227	InterPro	IPR011659	WD40-like beta propeller
236	271	Pfam	PF07676	WD40-like Beta Propeller Repeat
236	271	InterPro	IPR011659	WD40-like beta propeller
371	400	Pfam	PF07676	WD40-like Beta Propeller Repeat
371	400	InterPro	IPR011659	WD40-like beta propeller
279	314	Pfam	PF07676	WD40-like Beta Propeller Repeat
279	314	InterPro	IPR011659	WD40-like beta propeller
1	2	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
15	428	NCBIfam	TIGR02800	Tol-Pal system beta propeller repeat protein TolB
15	428	InterPro	IPR014167	Tol-Pal system protein TolB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0972	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.816

PA0972