Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0974
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cpoB PA0974
Status: annotated
Amino acids: 274
Structure source: AlphaFold

GO

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. GO:0070206 The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.756

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.
GO:0070206 The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
1	21	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
154	274	Pfam	PF13525	Outer membrane lipoprotein
154	274	InterPro	IPR039565	Outer membrane lipoprotein BamD-like
18	21	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	21	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
150	265	SUPERFAMILY	SSF48452	TPR-like
150	265	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
89	151	MobiDBLite	mobidb-lite	consensus disorder prediction
56	120	Gene3D	G3DSA:1.20.5.110	-
153	270	NCBIfam	TIGR02795	tol-pal system protein YbgF
153	270	InterPro	IPR014162	Cell division coordinator CpoB, C-terminal
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	21	Phobius	SIGNAL_PEPTIDE	Signal peptide region
61	116	Pfam	PF16331	TolA binding protein trimerisation
61	116	InterPro	IPR032519	YbgF, trimerisation domain
70	104	Coils	Coil	Coil
7	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
153	274	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
153	274	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
22	274	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	273	Hamap	MF_02066	Cell division coordinator CpoB [cpoB].
1	273	InterPro	IPR034706	Cell division coordinator CpoB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0974	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.756
1				0.358

PA0974