Protein profile

PA0985

pyocin S5

Genome: NC_002516.2

Gene: pyoS5 PA0985 Structure source: Experimental + AlphaFold UniProt Q9I4Y4
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Amino acids 498
Annotations 5
Features 23
PDB binders 0
Druggability 0.912

Overview

Basic information about this protein and its source genome.

Accession
PA0985
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pyoS5 PA0985
Status
annotated
Amino acids
498
Structure source
Experimental + AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872 Binding to a metal ion. GO:0140911 An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death. GO:0050829 Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. GO:0031640 Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.912
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0046872 Binding to a metal ion.
  • GO:0140911 An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
  • GO:0050829 Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
  • GO:0031640 Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
241 261 Coils Coil Coil
197 217 Coils Coil Coil
282 320 Coils Coil Coil
355 370 PRINTS PR00280 Channel forming colicin signature
355 370 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic
446 464 PRINTS PR00280 Channel forming colicin signature
446 464 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic
432 445 PRINTS PR00280 Channel forming colicin signature
432 445 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic
374 390 PRINTS PR00280 Channel forming colicin signature
374 390 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic
290 497 Gene3D G3DSA:1.10.490.30 Colicin
290 497 InterPro IPR038283 Channel forming colicin, C-terminal domain superfamily
453 478 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
220 497 SUPERFAMILY SSF56837 Colicin
1 452 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
479 498 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
453 475 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
174 194 Coils Coil Coil
310 494 Pfam PF01024 Colicin pore forming domain
310 494 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic
432 443 ProSitePatterns PS00276 Channel forming colicins signature.
432 443 InterPro IPR000293 Channel forming colicin, C-terminal cytotoxic

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6THK
X-ray 2.20 Å A
100.0% 1-498
PDBe RCSB PDBj File
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AlphaFold PA0985
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.912
2 0.352
4 0.333

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.71 0.276
2 2.78 0.085
3 1.5 0.021
4 1.19 0.01
5 1.15 0.009