Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA0994
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA0994 cupC3
Status: annotated
Amino acids: 839
Structure source: AlphaFold

GO

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.542

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
271	360	Gene3D	G3DSA:2.60.40.3110	-
759	820	Pfam	PF13953	PapC C-terminal domain
759	820	InterPro	IPR025949	PapC-like, C-terminal domain
755	836	Gene3D	G3DSA:2.60.40.2070	-
755	836	InterPro	IPR043142	PapC-like, C-terminal domain superfamily
34	162	Gene3D	G3DSA:3.10.20.410	-
34	162	InterPro	IPR037224	PapC, N-terminal domain superfamily
1	17	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	34	Phobius	SIGNAL_PEPTIDE	Signal peptide region
664	754	FunFam	G3DSA:2.60.40.2610:FF:000001	Outer membrane fimbrial usher protein
665	754	Gene3D	G3DSA:2.60.40.2610	Outer membrane usher protein FimD, plug domain
665	754	InterPro	IPR042186	Outer membrane usher protein FimD, plug domain
12	835	PANTHER	PTHR30451	OUTER MEMBRANE USHER PROTEIN
12	835	InterPro	IPR000015	Outer membrane usher protein
271	360	FunFam	G3DSA:2.60.40.3110:FF:000001	Putative fimbrial outer membrane usher
313	323	ProSitePatterns	PS01151	Fimbrial biogenesis outer membrane usher protein signature.
313	323	InterPro	IPR018030	Fimbrial membrane usher, conserved site
18	28	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
199	749	Pfam	PF00577	Outer membrane usher protein
199	749	InterPro	IPR000015	Outer membrane usher protein
36	184	Pfam	PF13954	PapC N-terminal domain
36	184	InterPro	IPR025885	PapC, N-terminal domain
29	34	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
35	839	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58	176	SUPERFAMILY	SSF141729	FimD N-terminal domain-like
58	176	InterPro	IPR037224	PapC, N-terminal domain superfamily
1	39	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA0994	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
9				0.542
13				0.322

PA0994