Protein profile

PA1015

transcriptional regulator

Genome: NC_002516.2

Gene: PA1015 Structure source: AlphaFold UniProt Q9I4V8
Export view
Amino acids 266
Annotations 4
Features 19
PDB binders 0
Druggability 0.743

Overview

Basic information about this protein and its source genome.

Accession
PA1015
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1015
Status
annotated
Amino acids
266
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.743
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTKDATTKGTSSKDVGAVVNAIQILRHLAHADGPQGVAAIARATGISPSSAFNILRTLSNERLTSFDDAGKTYQLGLGLSELAVGFVGRSYADLIQPELERLSLAHHILIALWQVTDDAHIRVIALAAPPVAHVNVAVGTRLPELVGAAGRCIAGLRELPEDELRRRLTRVRWENPPSFERYQAEATEAVERGWAIDQEHLYRGVSMVASAITDRDGQPRFAISAIGISAQHQPDDLERIGTSLRDTARFVSRALFPQGEALKEKS

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
90 257 Gene3D G3DSA:3.30.450.40 -
90 257 InterPro IPR029016 GAF-like domain superfamily
1 259 PANTHER PTHR30136 HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY
15 77 ProSiteProfiles PS51077 IclR-type HTH domain profile.
15 77 InterPro IPR005471 Transcription regulator IclR, N-terminal
134 253 Pfam PF01614 Bacterial transcriptional regulator
134 253 InterPro IPR014757 Transcription regulator IclR, C-terminal
10 87 Gene3D G3DSA:1.10.10.10 -
10 87 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
73 255 SUPERFAMILY SSF55781 GAF domain-like
15 86 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
15 86 InterPro IPR036390 Winged helix DNA-binding domain superfamily
17 64 Pfam PF09339 IclR helix-turn-helix domain
17 64 InterPro IPR005471 Transcription regulator IclR, N-terminal
78 257 ProSiteProfiles PS51078 IclR effector binding domain profile.
78 257 InterPro IPR014757 Transcription regulator IclR, C-terminal
15 104 SMART SM00346 iclrneu
15 104 InterPro IPR005471 Transcription regulator IclR, N-terminal
90 257 FunFam G3DSA:3.30.450.40:FF:000098 IclR family transcriptional regulator

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1015
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.743
4 0.201