Protein profile

PA1050

hypothetical protein

Genome: NC_002516.2

Gene: PA1050 Structure source: AlphaFold UniProt Q9I4S4

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Amino acids 370

Annotations 2

Features 9

PDB binders 0

Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession: PA1050
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1050
Status: annotated
Amino acids: 370
Structure source: AlphaFold

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records

Show feature table

Start	End	DB	Term	Name
239	366	Gene3D	G3DSA:1.10.10.2840	-
239	366	InterPro	IPR042070	PucR C-terminal helix-turn-helix domain superfamily
306	363	Pfam	PF13556	PucR C-terminal helix-turn-helix domain
306	363	InterPro	IPR025736	PucR C-terminal helix-turn-helix domain
7	364	PANTHER	PTHR33744	CARBOHYDRATE DIACID REGULATOR
4	137	Pfam	PF05651	Putative sugar diacid recognition
4	137	InterPro	IPR008599	Putative sugar diacid recognition
146	255	Pfam	PF17853	GGDEF-like domain
146	255	InterPro	IPR041522	CdaR, GGDEF-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1050	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.807
2				0.581
7				0.386