Protein profile

PA1051

transporter

Genome: NC_002516.2

Gene: PA1051 Structure source: AlphaFold UniProt Q9I4S3
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Amino acids 452
Annotations 4
Features 46
PDB binders 0
Druggability 0.802

Overview

Basic information about this protein and its source genome.

Accession
PA1051
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1051
Status
annotated
Amino acids
452
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015128 Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429 The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015128 Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose.
  • GO:0035429 The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

46 records
Show feature table
Start End DB Term Name
415 425 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
235 256 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
361 383 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
393 415 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 40 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
452 452 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
233 255 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
428 450 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 19 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
270 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
357 362 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
393 414 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
257 261 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
309 328 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 154 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 26 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
175 196 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
156 174 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
426 451 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
77 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 54 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
363 381 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
262 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 451 PANTHER PTHR30354 GNT FAMILY GLUCONATE TRANSPORTER
1 451 InterPro IPR003474 Gluconate transporter
382 392 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
174 196 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 450 Pfam PF02447 GntP family permease
1 450 InterPro IPR003474 Gluconate transporter
137 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
53 75 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
197 234 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
302 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
55 76 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
329 333 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
290 308 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
126 136 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1051
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.802
7 0.628
11 0.562
10 0.239