Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1059
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1059
Status: annotated
Amino acids: 115
Structure source: AlphaFold

GO

GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0035725 A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0015297 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0098662 OBSOLETE. A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.612

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
GO:0035725 A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
GO:0015297 Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
GO:0098662 OBSOLETE. A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
17	97	Pfam	PF03334	Na+/H+ antiporter subunit
17	97	InterPro	IPR005133	Na+/H+ antiporter subunit G
72	94	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
17	105	NCBIfam	TIGR01300	monovalent cation/H(+) antiporter subunit G
17	105	InterPro	IPR005133	Na+/H+ antiporter subunit G
100	115	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76	99	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
12	33	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
12	33	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
45	64	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
65	75	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34	44	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	11	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
48	65	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
8	114	PANTHER	PTHR34703	ANTIPORTER SUBUNIT MNHG2-RELATED
8	114	InterPro	IPR005133	Na+/H+ antiporter subunit G

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1059	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.612

PA1059