Protein profile

PA1074

branched-chain amino acid ABC transporter substrate-binding protein BraC

Genome: NC_002516.2

Gene: braC PA1074 Structure source: AlphaFold UniProt P21175
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Amino acids 373
Annotations 10
Features 29
PDB binders 1
Druggability 0.655

Overview

Basic information about this protein and its source genome.

Accession
PA1074
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
braC PA1074
Status
annotated
Amino acids
373
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015803 The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. GO:0042941 The process in which D-alanine, the D-enantiomer of 2-aminopropanoic acid, is transported across a lipid bilayer, from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0015818 The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015808 The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:1903806 The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.655
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0015803 The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings.
  • GO:0042941 The process in which D-alanine, the D-enantiomer of 2-aminopropanoic acid, is transported across a lipid bilayer, from one side of a membrane to the other by means of some agent such as a transporter or pore.
  • GO:0015818 The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015808 The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:1903806 The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol.
  • GO:0015820 The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:1903805 The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol.
  • GO:0015829 The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
28 366 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
28 366 InterPro IPR028082 Periplasmic binding protein-like I
29 366 Pfam PF13458 Periplasmic binding protein
29 366 InterPro IPR028081 Leucine-binding protein domain
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
148 276 Gene3D G3DSA:3.40.50.2300 -
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
2 373 PANTHER PTHR47151 LEU/ILE/VAL-BINDING ABC TRANSPORTER SUBUNIT
31 363 CDD cd06342 PBP1_ABC_LIVBP-like
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
31 351 Gene3D G3DSA:3.40.50.2300 -
27 373 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
281 294 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
281 294 InterPro IPR000709 Leu/Ile/Val-binding protein
333 348 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
333 348 InterPro IPR000709 Leu/Ile/Val-binding protein
30 46 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
30 46 InterPro IPR000709 Leu/Ile/Val-binding protein
258 276 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
258 276 InterPro IPR000709 Leu/Ile/Val-binding protein
92 102 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
92 102 InterPro IPR000709 Leu/Ile/Val-binding protein
52 68 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
52 68 InterPro IPR000709 Leu/Ile/Val-binding protein
71 89 PRINTS PR00337 Leu/Ile/Val-binding protein family signature
71 89 InterPro IPR000709 Leu/Ile/Val-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1074
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.655
1 0.33

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ABU
3IP9
Q7CX36 103.1 Da LogP -0.19 TPSA 63.3 ✓ Ro5 ✓ Clean C(CC(=O)O)CN

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.