Protein profile

PA1077

flagellar basal-body rod protein FlgB

Genome: NC_002516.2

Gene: PA1077 flgB Structure source: AlphaFold UniProt Q9I4Q2
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Amino acids 135
Annotations 4
Features 9
PDB binders 0
Druggability 0.826

Overview

Basic information about this protein and its source genome.

Accession
PA1077
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1077 flgB
Status
annotated
Amino acids
135
Structure source
AlphaFold
GO
GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0030694 The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.826
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0030694 The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings.
  • GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
5 133 NCBIfam TIGR01396 flagellar basal body rod protein FlgB
5 133 InterPro IPR006300 Flagellar basal-body rod protein FlgB
1 135 PIRSF PIRSF002889 Rod_FlgB
1 135 InterPro IPR006300 Flagellar basal-body rod protein FlgB
11 39 Pfam PF00460 Flagella basal body rod protein
11 39 InterPro IPR001444 Flagellar basal body rod protein, N-terminal
15 35 ProSitePatterns PS00588 Flagella basal body rod proteins signature.
15 35 InterPro IPR019776 Flagellar basal body rod protein, conserved site
6 57 PANTHER PTHR30435 FLAGELLAR PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1077
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.826