Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1080
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: flgE PA1080
Status: annotated
Amino acids: 462
Structure source: AlphaFold

GO

GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.628

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0009425 One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor.
GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body.
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
3	33	Pfam	PF00460	Flagella basal body rod protein
3	33	InterPro	IPR001444	Flagellar basal body rod protein, N-terminal
201	220	MobiDBLite	mobidb-lite	consensus disorder prediction
176	343	Pfam	PF07559	Flagellar basal body protein FlaE
176	343	InterPro	IPR011491	Flagellar hook protein FlgE
383	461	Pfam	PF06429	Flagellar basal body rod FlgEFG protein C-terminal
383	461	InterPro	IPR010930	Flagellar basal-body/hook protein, C-terminal domain
1	444	NCBIfam	TIGR03506	flagellar hook-basal body complex protein
1	444	InterPro	IPR020013	Flagellar hook-basal body protein, FlgE/F/G
1	460	PANTHER	PTHR30435	FLAGELLAR PROTEIN
80	423	SUPERFAMILY	SSF117143	Flagellar hook protein flgE
80	423	InterPro	IPR037925	Flagellar hook-basal body protein, FlgE/F/G-like
150	344	Gene3D	G3DSA:2.60.98.20	Flagellar hook protein FlgE
150	344	InterPro	IPR037058	Flagellar hook protein FlgE superfamily
149	178	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1080	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.628
4				0.365
1				0.295

PA1080