Protein profile

PA1081

flagellar basal body rod protein FlgF

Genome: NC_002516.2

Gene: flgF PA1081 Structure source: AlphaFold UniProt Q9I4P8

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Amino acids 249

Annotations 4

Features 11

PDB binders 0

Druggability 0.298

Overview

Basic information about this protein and its source genome.

Accession: PA1081
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: flgF PA1081
Status: annotated
Amino acids: 249
Structure source: AlphaFold

GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0030694 The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.298

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0030694 The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings.
GO:0071978 Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
4	121	NCBIfam	TIGR03506	flagellar hook-basal body complex protein
4	121	InterPro	IPR020013	Flagellar hook-basal body protein, FlgE/F/G
78	207	SUPERFAMILY	SSF117143	Flagellar hook protein flgE
78	207	InterPro	IPR037925	Flagellar hook-basal body protein, FlgE/F/G-like
5	35	Pfam	PF00460	Flagella basal body rod protein
5	35	InterPro	IPR001444	Flagellar basal body rod protein, N-terminal
5	226	NCBIfam	TIGR02490	flagellar basal-body rod protein FlgF
5	226	InterPro	IPR012836	Flagellar basal-body rod FlgF
1	237	PANTHER	PTHR30435	FLAGELLAR PROTEIN
171	239	Pfam	PF06429	Flagellar basal body rod FlgEFG protein C-terminal
171	239	InterPro	IPR010930	Flagellar basal-body/hook protein, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1081	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.298