Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1086
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1086 flgK
Status: annotated
Amino acids: 683
Structure source: AlphaFold

GO

GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005198 The action of a molecule that contributes to the structural integrity of a complex. GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.697

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MSDLLSIGLSGLGTSQTWLTVTGHNITNVKTPGYSRQDAIQQTRIPQFSGAGYMGSGSQIVDVRRLASDFLTGQLRNATSQNSELNAFLGQIDQLNSLLADNTTGVSPAMQRFFSALQTAAQNPSSTEAREAVLAQAQGLSKTFNTLYDQLDKQNSLINQQLGALTSQVNNLSQSVAEYNDAIAKAKSAGAVPNDLLDARDEAVRKLSEMVGVTAVTQDDNSVSLFIGSGQPLVVGNTVSTLSVVPGLDDPTRYQVQLTLGDSTQNVTRLVSGGQMGGLLAYRDTVLDSSYNKLGQLALTFADTVNKQLGQGLDLAGKAGANLFGDINDPDITALRVLAKNGNTGNVHANLNITDTSKLNSSDFRLDFDGTNFTARRLGDDASMQVTVSGTGPYTLSFKDANGVDQGFSVTLDQLPAAGDRFTLQPTRRGASDIETTLKNASQLAFAGSARAEATTNNRGSGAIGQPNLVDGPSPIDPAVLQNAFGANGLPLSATVSADGKTYTMTSPLPAGWSYVDKDGNALPGSPTLNSGTSNSVRMAYTDPGSGQTYTYEFNLSNVPQTGDSFTLSFNKDGIADNRNALNLNALQTKPTVGGTDSTGSTYNDAYGGLVERVGTLTAQARASADASQTVLKQAQDSRDSLSGVSLDEEAANLIQFQQYYSASAQVIQVARSLFDTLIGAFR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body.
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO:0005198 The action of a molecule that contributes to the structural integrity of a complex.
GO:0044780 The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
169	189	Coils	Coil	Coil
4	12	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
619	680	Pfam	PF06429	Flagellar basal body rod FlgEFG protein C-terminal
619	680	InterPro	IPR010930	Flagellar basal-body/hook protein, C-terminal domain
493	683	SUPERFAMILY	SSF64518	Phase 1 flagellin
1	17	Phobius	SIGNAL_PEPTIDE	Signal peptide region
18	683	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4	346	NCBIfam	TIGR02492	flagellar hook-associated protein FlgK
4	346	InterPro	IPR002371	Flagellar hook-associated protein 1
362	384	PRINTS	PR01005	Flagellar hook-associated protein signature
362	384	InterPro	IPR002371	Flagellar hook-associated protein 1
49	71	PRINTS	PR01005	Flagellar hook-associated protein signature
49	71	InterPro	IPR002371	Flagellar hook-associated protein 1
11	34	PRINTS	PR01005	Flagellar hook-associated protein signature
11	34	InterPro	IPR002371	Flagellar hook-associated protein 1
123	143	PRINTS	PR01005	Flagellar hook-associated protein signature
123	143	InterPro	IPR002371	Flagellar hook-associated protein 1
156	180	PRINTS	PR01005	Flagellar hook-associated protein signature
156	180	InterPro	IPR002371	Flagellar hook-associated protein 1
1	682	PANTHER	PTHR30033	FLAGELLAR HOOK-ASSOCIATED PROTEIN 1
1	682	InterPro	IPR002371	Flagellar hook-associated protein 1
1	3	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
13	17	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
138	457	SUPERFAMILY	SSF64518	Phase 1 flagellin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1086	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
13				0.644
18				0.53
14				0.224

PA1086