Protein profile

PA1087

flagellar hook-associated protein FlgL

Genome: NC_002516.2

Gene: flgL PA1087 Structure source: AlphaFold UniProt Q9I4P2

Export view

Amino acids 439

Annotations 5

Features 12

PDB binders 0

Druggability 0.66

Overview

Basic information about this protein and its source genome.

Accession: PA1087
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: flgL PA1087
Status: annotated
Amino acids: 439
Structure source: AlphaFold

GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005198 The action of a molecule that contributes to the structural integrity of a complex. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.66

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body.
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO:0005198 The action of a molecule that contributes to the structural integrity of a complex.
GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
3	140	Pfam	PF00669	Bacterial flagellin N-terminal helical region
3	140	InterPro	IPR001029	Flagellin, N-terminal domain
192	214	MobiDBLite	mobidb-lite	consensus disorder prediction
356	438	Pfam	PF00700	Bacterial flagellin C-terminal helical region
356	438	InterPro	IPR046358	Flagellin, C-terminal domain
1	438	SUPERFAMILY	SSF64518	Phase 1 flagellin
40	225	Gene3D	G3DSA:1.20.1330.10	-
263	435	Gene3D	G3DSA:1.20.1330.10	-
1	438	PANTHER	PTHR42792	FLAGELLIN
1	438	InterPro	IPR001492	Flagellin
2	438	NCBIfam	TIGR02550	flagellar hook-associated protein FlgL
2	438	InterPro	IPR013384	Flagellar hook-associated protein 3

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1087	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
10				0.66
4				0.257
1				0.215