Protein profile

PA1088

hypothetical protein

Genome: NC_002516.2

Gene: PA1088 Structure source: AlphaFold UniProt Q9I4P1
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Amino acids 253
Annotations 2
Features 8
PDB binders 2
Druggability 0.76

Overview

Basic information about this protein and its source genome.

Accession
PA1088
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1088
Status
annotated
Amino acids
253
Structure source
AlphaFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.76
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTDKQRIKGRPVAIDYESTLAFFEGRAAREYRNALSSTMYQDQQPELVEERDRREKLRVAPGLALGMARRVLDIGCGIGRWGWLLAEEAPQADYLGIDFSAALVEKACDEARQRGYERLLFQRMSATDIRPAELALSPPYDLLLVSGLLIYLNDSDCQELLRQALQLCAPGGRIYLREPVAVEQRLTLDRFFSKELEHEYSAVYRTVAELKDMLVQAGGGEGPAILEEDCLFAEALEKRVETRQYFMILQRRG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
70 176 CDD cd02440 AdoMet_MTases
70 200 Pfam PF13847 Methyltransferase domain
70 200 InterPro IPR025714 Methyltransferase domain
44 193 PANTHER PTHR43464 METHYLTRANSFERASE
11 244 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
11 244 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
50 218 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
50 218 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1088
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.76

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

12 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OPE
6WLF
A0A1I7RPU0 141.1 Da LogP -0.95 TPSA 92.8 ✓ Ro5 ✓ Clean C(COP(=O)(O)O)N
PC
5WP4
Q9FR44 184.2 Da LogP -0.20 TPSA 66.8 ✓ Ro5 ✓ Clean C[N+](C)(C)CCOP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.