Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1091
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: fgtA PA1091
Status: annotated
Amino acids: 1694
Structure source: AlphaFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047355 Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. GO:0000271 The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.595

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MIEDSVSEPDRRDGGDAGKRLAWLQRQVLPVLEEGGAVWVSGLDGAPFAGGAHKVVEASVAGELPGNERFRLACLGGAVGGVADDWQAMRLLLRAVESLEDRGWLLLEEALSVSAAGACRSPQAQARLALSLGLRQVAELRLGAPDDGGRQRVLQLFRQDLAVARMQRYSGLRVACYGNMPFHYRSLRPLAECFEDSLLSLDIDEVMAWKPDVIAVADGWSVEFWRDYCDAHNVLLVGMRHGSVTRYGFAEGTYRYADYLCGSAWDIDDTLASSVMPRNGFLLTGNAWCDEVFRLPARTPAENAPTILFAPTYNPEISAAVHLGERVVALIRKVYPASRIIIKPHPAIVQHEHAFVSDKDLFRDLMKLWREQSRTDPLVTLVDDPEASIAASFAEADILLADRSSLIFEFMTLDRPILLFSREQRIARWAYNPEAPGNAWRDIGLEFADDEQLLDLLANAFTRHAESRDTQENRTQQLYGRFRDGRSVQRVAAAIAEAPRLQIVLDARAAADGGQRLAEHYAACFAHRRIDLIAPSGAALPADVRRFDSWRAWCDAEAATLERRASAVLLVEDDGQLLPGSAHQVSALLPAIAMGQLRHARLALEEREAGPAGETDWSARRLHRLLARLQPKPAWRLLAPALLREELADLPDEAEQPLWLRAVAAAEAPVEWPVGQLNLFAEEGLLRQGDVHMLCARARLRAVPCVSGLPLRQRQVVLQVTPFASQLYDRFPFQLRVCLNGQLFSRVSVEDARAKSLVLPFRGDERGGMTIELECDGSYPAFEGVSTPVSLLLQTAFQPAPGDYCAALAAGAASPEAGEDLRSEYETWLHGREVEPARYRPFIDALRRDSRIEVLVLAEEAEDADLQRSLASIDGQALPAWRTRILGRAPAFARKGLAWLAEGGSAAERINLAAAASDADWLIVIHAGDELARSALLLLAEKIRTETALLCCYSDEDHVCDGRYEAPLLKPDFNLDLLRSYPYCGRSLAFQRAALLAQGGLQEGFGDLALQDFMFRLAEREGLDRIGHLAEVLYHSARAFGEWLASAAVRPFIASVVDEHLNRLGVPHRIEPGRLAVINRIAYDYPGTPAVSLLLPVGDSLSALQRSVESFLENTDYPSYELLLVASGPLAPDMAAWLEAVQGLGSEQIRVLSPQASSLAGCLNLCVAEARGEFLLSLGAGVVALRPDWLRELLNHGRRPEVGAVGGKLLGLDGTIREAGLVLGLGGTAGRAFAGEAGDSAGYMHRLLVVQNHTALSASCLLFKRSLHDELGGFDENDFAHGHADVDFSLRARQLGYLSVWTPYAILAQNGNVELPSVEADESLYRRWLPALARDPAYNRNLSLEGAGFALERPEVPAWQPLFGRSPLPRVLAHPADPYGCGHYRVRQPFRALHDAGLLDGMLSESLLQPVALERLEVDSVILQRQISEEQLRAISRMRSFNRAFRVYELDDYLPELPLKSLHRAEMPGDIRQILGRALGLADRFVVSTEPLAEAFRRMHGDIRVVPNRLPLPWWRDLSSRRRDAERPRVGWAGGIGHGGDLEVIAEVVRELADEVDWVFFGFCPDALRPYVREYHPGVEIERYPAYLASLDLDLALAPLEQNRFNECKSNLRLLEYGVLGFPVICSDVLCYRDSLPVTRVKNRSRDWLEAIRAHLADADANAAAGAQLREAVRRDWMLEGAHLEAWAAAWLPD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0047355 Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP.
GO:0000271 The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records

Show feature table

Start	End	DB	Term	Name
298	482	Gene3D	G3DSA:3.40.50.12580	-
298	482	InterPro	IPR043148	CDP-glycerol glycerophosphotransferase, C-terminal domain
1412	1677	SUPERFAMILY	SSF53756	UDP-Glycosyltransferase/glycogen phosphorylase
1413	1433	Coils	Coil	Coil
1091	1308	SUPERFAMILY	SSF53448	Nucleotide-diphospho-sugar transferases
1091	1308	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
264	496	Pfam	PF04464	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
264	496	InterPro	IPR007554	CDP-glycerol glycerophosphotransferase
901	1070	Gene3D	G3DSA:3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
901	1070	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
1078	1314	Gene3D	G3DSA:3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
1078	1314	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
203	496	SUPERFAMILY	SSF53756	UDP-Glycosyltransferase/glycogen phosphorylase
902	1035	SUPERFAMILY	SSF53448	Nucleotide-diphospho-sugar transferases
902	1035	InterPro	IPR029044	Nucleotide-diphospho-sugar transferases
1516	1664	Gene3D	G3DSA:3.40.50.2000	Glycogen Phosphorylase B;
632	1679	PANTHER	PTHR43685	GLYCOSYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1091	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
8				0.595
2				0.406

PA1091