Protein profile

PA1094

B-type flagellar hook-associated protein

Genome: NC_002516.2

Gene: fliD PA1094 Structure source: Experimental + AlphaFold UniProt Q9K3C5
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Amino acids 474
Annotations 6
Features 9
PDB binders 0
Druggability 0.736

Overview

Basic information about this protein and its source genome.

Accession
PA1094
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
fliD PA1094
Status
annotated
Amino acids
474
Structure source
Experimental + AlphaFold
GO
GO:0009421 The proteinaceous structure at the distal tip of the bacterial-type flagellar filament. GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.736
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MAGISIGVGSTDYTDLVNKMVNLEGAAKTNQLATLEKTTTTRLTALGQFKSAISAFQTALTALNSNAVFMARTAKSSNEDILKASATQSAVAGTYQIQVNSLATSSKIALQAIADPANAKFNSGTLNISVGDTKLPAITVDSSNNTLAGMRDAINQAGKEAGVSATIITDNSGSRLVLSSTKTGDGKDIKVEVSDDGSGGNTSLSQLAFDPATAPKLSDGAAAGYVTKAANGEITVDGLKRSIASNSVSDVIDGVSFDVKAVTEAGKPITLTVSRDDAGVKDNVKKFVEAYNTLTKFINEQTVVTKVGEDKNPVTGALLGDASVRALVNTMRSELIASNENGSVRNLAALGITTTKDGTLEIDEKKLDKAISADFEGVASYFTGDTGLAKRLGDKMKPYTDAQGILDQRTTTLQKTLSNVDTQKADLAKRLAALQEKLTTQFNLLSAMQDEMTKRQKSITDNLASLPYGSGKKT

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0009421 The proteinaceous structure at the distal tip of the bacterial-type flagellar filament.
  • GO:0009424 The portion of the bacterial-type flagellum that connects the filament to the basal body.
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0071973 Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009288 A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
229 452 Pfam PF07195 Flagellar hook-associated protein 2 C-terminus
229 452 InterPro IPR010809 Flagellar hook-associated protein 2, C-terminal
417 437 Coils Coil Coil
125 182 Pfam PF07196 Flagellin hook IN motif
125 182 InterPro IPR010810 Flagellin hook, IN motif
1 465 PANTHER PTHR30288 FLAGELLAR CAP/ASSEMBLY PROTEIN FLID
1 465 InterPro IPR040026 Flagellar hook-associated protein 2
11 105 Pfam PF02465 Flagellar hook-associated protein 2 N-terminus
11 105 InterPro IPR003481 Flagellar hook-associated protein 2, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5FHY
X-ray 2.20 Å A,B
69.2% 78-405
PDBe RCSB PDBj File
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AlphaFold PA1094
AlphaFold — — full sequence — Loaded
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.736